Reducing Effect of Strobilanthes crispus Leaf Extract in Hepatocarcinogenesis Rats
نویسندگان
چکیده
The effect of Strobilanthes crispus extract and glycyrrhizin in on rats induced with carcinoma is reported. The results showed significant, increase of liver microsome glutathione s-transferase (GST) in rats after 12 weeks. Treatment with glycyrrhizin caused decrease in liver GST activity compared to control. Treatment with Strobilanthes crispus extract caused overall decrease in liver GST activity almost close to control groups. The microscopic observation of the lesion score during hepatocarcinogenesis revealed that cells of cancer group without treatment were severely necrotic at week 12. However, cells of cancer group with S. crispus treatment appeared normal at the same period.
منابع مشابه
Chemopreventive effects of Strobilanthes crispus leaf extract on azoxymethane-induced aberrant crypt foci in rat colon
In this work, microscopic and histological studies suggest that Strobilanthes crispus ethanol extract reduce azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in rats. S. crispus is considered a traditional medicine and used as an antioxidant. Its leaf contains a large amount of phenolic compounds to which its radical scavenging role is attributed and enhance its ability to eradicate...
متن کاملAnticancer activity of a sub-fraction of dichloromethane extract of Strobilanthes crispus on human breast and prostate cancer cells in vitro
BACKGROUND The leaves of Strobilanthes crispus (S. crispus) which is native to the regions of Madagascar to the Malay Archipelago, are used in folk medicine for their antidiabetic, diuretic, anticancer and blood pressure lowering properties. Crude extracts of this plant have been found to be cytotoxic to human cancer cell lines and protective against chemically-induced hepatocarcinogenesis in r...
متن کاملIn vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell
BACKGROUND Strobilanthes crispus has been traditionally used as antidiabetic, anticancer, diuretic, antilytic and laxative agent. However, cytotoxicity and antiproliferative effect of S. crispus is still unclear. RESULTS Strobilanthes cripus was able to reduce cell viability and proliferation in MTT and BrdU assays. Both cell cycle progression and Tunel assay suggested that IC50 of S. crispus...
متن کاملAnti-Tumor Action, Clinical Biochemistry Profile and Phytochemical Constituents of a Pharmacologically Active Fraction of S. crispus in NMU-Induced Rat Mammary Tumour Model
Cancer patients seek alternative remedies such as traditional medicinal plants for safe and effective treatment and help overcome the side effects of conventional therapy. Current knowledge indicates that extracts of Strobilanthes crispus of the Acanthaceae family exhibit potent anticancer properties in vitro and are non-toxic in vivo. S. crispus was also reported to be protective against chemi...
متن کاملChemical Constituents and Biological Activities of Strobilanthes crispus L
Phytochemical investigation of Strobilanthes crispus has led to the isolation of 1-heptacosanol (1), tetracosanoic acid (2), stigmasterol (3) from the hexane extract, a mixture of four C20-C24 fatty acid esters of βamyrin (4), taraxerol (5), taraxerone (6), a mixture of two C22 and C24 fatty acid esters of taraxerol (7) from the dichloromethane extract, 4-acetyl-2,7-dihydroxy-1,4,8-triphenyloct...
متن کامل